Regulation of Notch 1 signaling in THP-1 cells enhances M2 macrophage differentiation
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چکیده
منابع مشابه
Regulation of Notch 1 signaling in THP-1 cells enhances M2 macrophage differentiation.
Macrophage polarization is emerging as an important area of research for the development of novel therapeutics to treat inflammatory diseases. Within the current study, the role of Notch1R in macrophage differentiation was investigated as well as downstream effects in THP-1 monocytes cultured in "inflammation mimicry" media. Interference of Notch signaling was achieved using either the pharmace...
متن کاملRegulation of Notch1 Signaling in THP-1 Cells Enhances M2 Macrophage
1 Regulation of Notch1 Signaling in THP-1 Cells Enhances M2 Macrophage 2 Differentiation 3 4 Reetu D. Singla, Jing Wang, and Dinender K. Singla 5 Biomolecular Science Center, Burnett School of Biomedical Sciences, College of 6 Medicine, University of Central Florida, Orlando, FL, 32816 USA 7 8 9 10 11 12 13 14 Running Title: Notch-1 in Macrophage Differentiation 15 16 17 Address for corresponde...
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Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions. Although hepcidin has been shown to affect ferroportin expression in macrophages, whether it affects macrophage polarization is still largely unknown. Objective: To address whether hepcidin ind...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2014
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00896.2013